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Primary Sclerosing Cholangitis (PSC)

Primary Sclerosing Cholangitis

Introduction

Primary sclerosing cholangitis is a chronic disease of the "hepatobiliary system". It is an inflammatory disease of the liver and gall bladder that leads to scar formation in the bile ducts that usually drain the bile from the gallbladder and passes it to the bowel to help digestion of fats.

In primary sclerosing cholangitis, the bile ducts are usually blocked due to inflammation, scarring and fibrosis. Because of this the bile starts accumulating inside the liver (as the liver is the organ that produces bile) in turns develops pressure on the liver and impairs its functions, hence, it gives rise to a severe complication as liver damage or liver cirrhosis. The incidence ratio is higher in males, and in the middle-aged group.

As per Ayurveda any inflammation inside the body occurs due to the vitiation of all the three doshas especially the pitta dosha as liver is the prime site of pitta in our body.

What are the Causes of Primary Sclerosing Cholangitis?

The exact etiology is still unknown but some causative factors are :-

  • Dietary factors like - Excessive consumption of spicy, sour, hot foodstuffs like - refined foods, non-vegetarian food, sauces, chilly, etc.
  • Lifestyle management - Sedentary lifestyle, excessive exposure to harmful radiations, excessive fasting, irregular food habits, aggravates pitta dosha in our body.
  • Genetic predispositions
  • Any cause that leads to hormonal imbalance may develop this condition.
  • Any disease history of autoimmune disorders
  • Some 'RISK FACTORS' are -
    1. Hepatitis
    2. Excessive intake of Alcohol
    3. Obesity

What are the Signs and Symptoms of Primary Sclerosing Cholangitis?

The most common symptoms of this disease are :-

  • Pain in the right hypochondriac region
  • Acidity
  • Itching
  • Splenomegaly (enlarged spleen)
  • Hepatomegaly (enlarged liver)
  • Dark urine (due to obstructed bilirubin)
  • Dark stool (absence of stercobilin)
  • Yellowness of skin, eyes, nails, etc.
  • Portal hypertension
  • Fever
  • Chills
  • Indigestion
  • Malabsorption
  • Weakness

Classification

Primary sclerosing cholangitis can be classified into three categories, they are :-

  • Classic Primary Sclerosing Cholangitis
  • Small-duct Primary Sclerosing Cholangitis
  • Primary Sclerosing Cholangitis associated with autoimmune hepatitis.

Diagnostic Criteria

On the clinical basis a diagnosis of the disease is not confirmed hence, some of the laboratory investigation is necessary like :-

  • Serum alkaline phosphatase (ALP)
  • USG (Ultrasonography)
  • ERCP (Endoscopic retrograde cholangiopancreatography)
  • MRCP (Magnetic resonance cholangiopancreatography)
  • Immunological assay
  • Liver biopsy

Management Criteria

As per Ayurveda the management criteria include :-

  • Measures to balance tridoshas
  • Detoxification of the body (to excrete aama /toxins)
  • Reduce inflammation and, clear the obstruction.
  • Heal the erosion (scarring)
  • Restore the normal functions of the liver and gallbladder.

Herbal Remedies for Primary Sclerosing Cholangitis

Rajamruth Vaidyashala is offering various formulations that are prepared from the purely natural herbs, natural minerals and calcium compounds. To tackle 'Primary Sclerosing Cholangitis', Rajamruth Vaidyashala came with the 'Liver Care Pack' which is composed of various effective herbs.

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The information presented on this website is solely intended for educational purposes and should not be considered a replacement for professional medical advice, diagnosis, or treatment. The statements and details on this site have not been assessed by the Food and Drug Administration. Our herbal products are entirely natural, pure, vegetarian, and efficacious. Individual results may differ, and it is advisable to consult with your healthcare professionals before using these products.